2(5H)-Furanone, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-4-(methylsulfonyl)phenyl-

Name	Firocoxib
Synonyms	Equixx Librens Equioxx FIROCOXIB Firocoxib ML 1785713 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2- one 2(5H)-Furanone, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-4-(methylsulfonyl)phenyl- 3-(Cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
CAS	189954-96-9
EINECS	200-001-2

Molecular Formula	C17H20O5S
Molar Mass	336.4
Density	1.31
Melting Point	78-80°C
Boling Point	563.9±50.0 °C(Predicted)
Solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White to Off-White
Storage Condition	Sealed in dry,Store in freezer, under -20°C
In vitro study	The COX-1:COX-2 selectivity ratios generally are established by comparing the IC 50 for COX-1 to the IC 50 for COX-2. The IC 80 value more closely resembles the steady-state plasma drug concentration than does the IC 50 value.The selectivity ratio for Firocoxib based on the IC 80 values is 121 (IC 80 of 0.36 μM and 43.6 μM for COX-2 and COX-1, respectively), indicating that selectivity for COX-2 is not reduced at concentrations higher than the IC 50 . Notably, Firocoxib concentrations that yield 80% to 95% inhibition of COX-2 produce < 20% inhibition of COX-1.

Last Update：2024-01-02 23:10:35

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CAS: 189954-96-9
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2(5H)-Furanone, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-4-(methylsulfonyl)phenyl- Request for Quotation